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Skin tumors
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Skin tumors

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Benign tumors, malignant tumor, skin cancer – we carry out consultation on receiving full treatment at cancer.

Help in receiving treatment by the cancer patient. New methods of a cancer therapy. The help in receiving an effective cancer therapy at any stage of cancer. Treatment of a melanoma, a uterus cancer therapy, a cancer therapy of lungs, a liver cancer therapy, a cancer therapy of a mammary gland, a pancreatic cancer new methods of a cancer therapy, leading experts How to receive effective treatment, effective methods of a cancer therapy how to choose clinic where you will be helped - we know answers to these questions. not in all clinics treat fully and effectively. Treatment of a tumor is possible only in case of application of effective including experimental techniques (including applied to ""). Life of the patient depends only on whether the necessary in this case technique of a cancer therapy is applied or not. the malignant tumor will recede only at application of full and complex treatment

Skin melanoma Risk factors and prevention. A skin melanoma – the malignant new growth arising owing to a malignization (regeneration) of pigmentary cages - melanotsit which are available in skin of each person since the birth. These cages produce a pigment melanin by which amount skin color of the person is defined. The melanoma can arise on not changed skin, but most often it develops against a pigmentary nevus, so - called birthmarks which present themselves congestions of melanotsit in the form of nests in different layers of skin. On average each person has about 50 nevus of various form and coloring. Usually they look as flat or slightly convex spots from light brown to a gray and black shade, with an equal contour and a smooth surface. Sometimes a "huge" nevus meets warty growths and indumentum. Under the influence of various factors harmless "birthmark" can develop into one of the most malignant and tumors hard to cure.

The melanoma is the most aggressive among skin tumors. Though its share among all malignant new growths of skin makes 3 - 5% , but the strong gain of incidence of a melanoma for the last decade worldwide, especially in the northern countries is noted.

There is a lot of reasons promoting development of a melanoma of skin. First of all it should be noted a skin travmatization, and first of all, a pigmentary nevus (birthmarks). The melanoma can arise as at a single trauma (a cut, blow, a burn), and at a chronic travmatization (constant friction clothes, footwear, professional injuries) a nevus. Considering it, whenever possible the travmatization of a pigmentary nevus should avoid, and at any, even minor change of the sizes, colourings and forms of the injured "birthmark" it is necessary to address the oncologist at once. And it is impossible to try to delete, cauterize or grease with folk remedies the changed pigmentary nevus at all. Only the specialized oncologist can precisely define nature of changes on skin and define the correct tactics of treatment. It should be noted that the injured nevus mostly is subject to surgical removal.

Not less important factor promoting development of a melanoma is ultra - violet radiation. People who by the nature of the activity bigger time are on the sun have regularly a rest in the south or visit a sunbed, first of all melanomas are subject to risk of developing of tumors of skin, and. UF - radiation is most dangerous to persons with the low level of pigmentation of an organism which certificate are white skin color, a fair hair and eyes, existence of a large number of freckles on skin. People with a light phenotype of a malovospriimchiva to solar suntan are also predisposed to development of solar burns because of high sensitivity to UF - radiation. Such people are recommended to avoid suntan and to watch carefully skin, especially open parts of the body. Detection of suspicious spots, plaques, or increase in the sizes of the existing nevus, change of their form and contours, emergence of an itch, bleeding in their area has to guard. In this case it is necessary to address in specialized oncological institution at once, it is desirable, passing local policlinics and doctors of not oncological profile. On the other hand, oncological vigilance of therapists, dermatologists and surgeons of the general profile to whom patients with "suspicious" formations of skin most often get is not less important.

The risk of developing of a melanoma of skin is high among people who are affected by chemical cancerogenic factors. These are workers of pharmaceutical industry, the petrochemical, rezinoizgotavlivayushchy enterprises, miners, etc. Such persons should avoid whenever possible contact of cancerogenic substances with open skin and to be observed periodically at an onkodermatolog.

Development of a melanoma of skin is quite often provoked by hormonal reorganization of an organism during pregnancy, a lactation, at reception of oral contraceptives, during the climacteric period. More frequent incidence of a melanoma at women in comparison with men is explained by it. The role of hormonal factors in development of a melanoma of skin dictated the standard opinion of oncologists that a "melanomoopasny" pigmentary nevus needs whenever possible to be deleted before puberty. To pertinently emphasize that at children's age the melanoma arises extremely seldom, however rapid growth of birthmarks at children is the indication for their surgical removal.

Incidence of a melanoma is connected also with a racial and ethnic origin – at representatives of light races incidence is several times higher, than at dark; with hereditary factors – the risk of development of a tumor is increased at the immediate family of patients with a melanoma; with immune and endocrine violations in an organism.

Diagnosis of a melanoma of skin consists first of all of visual survey of education taking into account anamnestichesky data (i. e. existence duration as the tumor during the entire period of development changed). Signs of a malignization of a pigmentary nevus which will allow to distinguish a melanoma at an early stage are essential and to provide effective timely treatment. Initial stages of transition of a nevus to a melanoma: 1. Growth of both the horizontal, and vertical sizes of a nevus for the short period 2. Disappearance of skin drawing, emergence of a glossy, brilliant surface of a nevus 3. Change of a form (asymmetry, festonchatost of edges) and colourings of a nevus (darkening or enlightenment). 4. Loss of a hair over a nevus 5. Bleeding at contact 6. Emergence of subjective feelings – an itch, burning, pain. The "displastichesky" nevus which is present at a large number at skin of people with a light phenotype malignizirutsya most often (blue - eyed blondes, red - haired).

There are 2 main forms of growth of a melanoma – superficial rasprostanyayushchayasya and nodal. The most aggressive nodal melanoma at which there is a deep invasion of a tumor in skin layers (vertical growth) that leads to increase in metastatic potential of a tumor. Unlike other tumors where the absolute sizes of a tumor matter, the main morphological characteristics at a melanoma are invasion level according to Clark (5 levels of an invasion) and tumor thickness across Breslou (in millimeters) measured under a microscope. The more the level of an invasion and thickness of a tumor, the is worse the forecast of a disease.

It should be noted that the above - named criteria can be defined only after removal of a tumor and histologic research of operational material. Initially melanomas are applied to preoperative diagnostics cytologic methods of research – soskob from a tumor, a tonkoigolny biopsy, dab - a print, etc.

Metastazirovaniye of a melanoma occurs in the form of limfogenny and hematogenic distribution of a tumor. Limfogenny metastasises can be in the form of defeat of lymph nodes of the corresponding zone (cervical, axillary, inguinal) or in the form of so - called "transit" metastasises - tumoral knots in soft fabrics at a short distance from primary tumor.

Metastatic damage of lymph nodes is diagnosed by survey, a palpation of knots and ultrasonic research. There are also special methods of research of lymph nodes, suspicious on metastasises, – a limfostsintigrafiya, a sentinelny biopsy, etc.

From the remote bodies the liver, bones, soft fabrics, a brain, lungs, adrenal glands most often are surprised. The metastazirovaniye in various bodies by means of tool methods of research – a X - ray analysis, a magnetic and resonant or computer tomography, ultrasonography is established. Isotope methods – a limfostsintigrafiya, a positron and issue tomography are often applied.

Recently definition of a melanomny onkomarker in blood – S - 100 anti - gene is widely applied to specification of the fact of progressing.

Treatment. Only timely surgical treatment can give chance of treatment from a tumor. Adequate surgical treatment with observance of the oncological principles has huge value for the forecast of a disease. It consists in broad excision of a tumor with surrounding fabrics under the general anesthesia (anesthesia), otstupya from visible borders of a tumor on 3 cm. The factor worsening the forecast is removal of a tumor under local anesthesia that promotes distribution of a tumor on blood and lymphatic vessels, and also development of local recurrence. Are unacceptable also ''burning out'' and ''scraping'', including with the diagnostic purpose that it is widespread especially in the cosmetology centers. Unfortunately the percent of diagnostic mistakes at doctors of the general medical network, and inadequate treatment of a melanoma at surgeons is high, dermatocosmetologists harmful influences the remote results. Adequate treatment of regionarny metastasises – performance of a regionarny limfadenektomiya is especially important that it is possible only in specialized oncological clinic. At metastasises in cervical lymph nodes Krayl's operation – a radical cervical limfadenektomiya is carried out, at metastasises in axillary lymph nodes – an axillary limfadenektomiya, at metastasises in inguinal and femoral lymph nodes – an inguinal and femoral limfadenektomiya (Dyuken's operation). Knife biopsies and a vylushchivaniye of metastatic lymph nodes are also the gross blunder promoting progressing of a tumor on regionarny limfoputyam. It should be noted that it is a little specialized centers for treatment of a melanoma of skin in our city. (Scientific research institute of oncology of N. N. Petrov, city clinical oncology dispensary).

Timely excision of the superficial extending melanoma (tumor thickness to 2 mm) provides satisfactory result of treatment (to 80 - 90% of survival). In the presence of regionarny metastasises in lymph nodes the survival considerably worsens. It correlates with the number of the affected lymph nodes. If it is struck with micrometastasises to 3 lymph nodes inclusive, the radical limfadenektomiya provides to 35 - 40% survival. It should be noted that application of additional therapy (himio - , an immunotherapy), widely applied till last years after radical operation, authentically does not improve results of treatment. Usually as additional (adjyuvantny) therapy long reception of interferon an alpha (roferon, reaferon) in the form of subcutaneous injections is appointed. Unfortunately, the melanoma belongs to tumors with small sensitivity to medicines and treatment of a disseminirovanny (metastatic) tumor has palliative character, i. e. pursues the aim of improvement of quality of life and increase in its duration. Treatment in this stage is impossible. Except standard cytostatic chemotherapy the immunotherapy – interferona, interleykina is often applied. In recent years developments of different types of vaccines – autologichny, homologous and ksenovaktsin are actively conducted. Efficiency of vaccinotherapy is so far in an assessment stage as various oncological centers of the world and unambiguous results of treatment deal with this problem is not published yet.

At single metastasises (in a brain, easy, soft fabrics) their surgical removal with the subsequent application of system therapy is sometimes shown. Radiation therapy in treatment of a melanoma is not applied. Absolute majority of pigmentary tumors of a radiorezistentna.

The patients cured of a melanoma it is necessary to observe a long time. Unlike many other tumors, the melanoma can progress even in 20 years! The period is shorter bezretsidivny (the period before progressing), the forecast of a disease is worse.

One of the leading scientific clinical centers in our country which are engaged in treatment of a melanoma of skin since 1960th, is the scientific research institute of Oncology of N. N. Petrov. In its walls tactics and a technique of surgeries on primary tumor and the regionarny lymphatic device are developed. In clinic all modern methods of treatment of disseminirovanny forms of tumors - vaccinotherapy, an immunotherapy by dendritny cages, photodynamic therapy, various modes of chemotherapy, including application of the molecular aimed preparations (targetny therapy) are carried out. The wide diagnostic arsenal of definition of extent of distribution of a tumor is applied that is extremely important for the choice of the correct tactics of treatment.

Improvement of results of treatment of a melanoma of skin is possible at application of an arsenal of screening methods for detection of a tumor at the earliest stage. A way of improvement of the forecast at generalized patients - development of new high - tech methods of local and system impact on a tumor.

It is important to remind that melanotsita exist also in other body tissues, except skin – an eye iris of the eye, mucous membranes of gastrointestinal and urethral paths, genitalia. From extra skin localizations of a melanoma which makes about 10% of all melanomas the most frequent is the melanoma of an eye, rectum, vulva.

Candidates of Medical Science. S. M. Ergnyan

Scientific Research Institute of Oncology of N. N. Petrov Rosmedtekhnology Federal State Institution

OTHER TUMOURS OF SKIN

  • Benign tumors of skin
  • papilloma
  • seboreyny wart
  • keratoakantoma
  • pigmentary nevus
  • dermatofibroma (fibroma)
  • angioma
  • lipoma
  1. Malignant tumors of skin
  2. Precancer diseases of skin
  • bazalioma (bazalno - cellular epitelioma)
  • ploskokletochny cancer (skvamozno - cellular carcinoma)
  • melanoma
  • Kaposha's sarcoma
  • skin lymphoma
  • aktinicheskiya keratoz (solar keratoz, senile keratoma)
  • Bowen's illness

SKIN TUMOURS.

Skin of the person represents the natural live barrier protecting an organism from influence from the outside and therefore it more than other fabrics, is subject to influence of adverse ecological and professional factors.

Not incidentally in the general structure of malignant new growths of a tumor of skin in the majority of the countries become the most often found oncological diseases.

The difficult structure of skin includes cells of various fabrics, each of which can undergo malignant transformation. A large number of various types of tumors which can arise in skin is explained by it. However the vast majority of them is presented by three types of malignant new growths: melanoma, ploskokletochny cancer of skin (skvamozno - cellular carcinoma) and bazalno - cellular cancer (bazaliom).

Ultra - violet radiation is the major factor inducing developing of such disease as a skin cancer. The critical role of sunlight is proved by studying of a set of genetic defects (including at skin new growths), and also more frequent localization of separate types of tumors on open parts of a body and the bigger frequency of their emergence in the countries with warm climate. Also can lead influence of cancerogenic chemical agents to developing of cancer of skin, such as arsenic and aromatic hydrocarbons.

The main method of prevention of cancer of skin has to be directed to identification of precancer changes and background conditions of skin since their timely treatment can completely change pathological process and prevent malignant transformation. Many proliferative, dystrophic, diskeratotichesky processes in skin, and also chronic inflammatory processes can lead to developing of cancer of skin:

  • senile keratoza and atrophies
  • aktinichesky keratoza
  • professional atrophies of skin
  • benign tumors
  • chronic radiation injury of skin
  • late radiation dermatitis
  • it is long the existing trophic ulcers
  • chronic ulcer and vegetiruyushchy piodermiya
  • ulcer and warty forms red flat depriving
  • cicatricial changes of skin in the centers of an eritematozny and tubercular volchanka
  • limited precancer giperkeratoz red border of lips, keloids
  • postburn hems

Degree of malignant potential of each of the specified precancer conditions of skin is various. So, aktinicheskiya keratoz develops in an invasive ploskokletochny cancer of skin in 1 - 10% of cases, carcinomas from postburn hems are noted in 5 - 6% of cases; at the same time they have faster evolution and more malignant current.

From the benign epitelialny tumors inclined to a malignization, it should be noted a skin horn (the malignization is observed in 12 - 20% of cases) and keratoakanty (in 17, 5% ). Warts and papillomas are not precancer diseases, however there is a number of situations, at kotorykhrak skin can develop also from them. More often it happens in cases of peaked condylomas, in the presence of warts at patients to an immunodeficiency, and also in case of genetically determined, so - called warty dysplasia of epidermis.

Especially it is necessary to stop on often found syndrome of a displastichesky nevus. Considering the high malignant potential of a displastichesky nevus, it is important to fix the first clinical symptoms of the begun dysplasia: fast asymmetric increase in sizes (more than 5 mm), unevenness of pigmentation or its combination with eritemy, emergence of faltering borders, a rim of a pobledneniye or hyperpegmentation of skin, feeling of "feeling" of a nevus (an itch, paresteziya). At the same time simultaneous noticeable fast increase in total of a nevus can also be a dangerous signal. It is necessary to take into account that at members of families with a syndrome of a displastichesky nevus the probability of development of a melanoma is 100 times higher, than in the general population.

Considering importance of early diagnosis of tumors of skin, we give the short characteristic of the most often found diseases united by the term of "a skin new growth" below.

BENIGN TUMOURS OF SKIN.

Papilloma.

Papilloma – the benign tumor connected with excess development of epidermis. Clinically papilloma represents accurately delimited warty growths of various size and a form towering over skin with the fleecy uneven surface deprived of indumentum, dirty - gray or brownish color. Sometimes papillomas are covered with easily tearing away horn masses. Grow slowly, for many years.

Seboreyny wart.

Seboreyny wart (senile wart, bazalno - cellular papilloma) – the benign tumor connected with violation of a differentiation of bazalny cells of epidermis, representing accurately delimited towering papule or a plaque with a hilly surface. Meets at persons of advanced and senile age on the closed parts of the body, the person and hairy part of the head more often. Senile warts have an appearance of papules and plaques of a rounded or oval shape yellowy - brown, sometimes almost black coloring, accurately delimited, rising over a surface of skin and with slightly flat warty surface (reminding the lump of chewing rubber pasted to a firm surface in a form). Diameter of a tumor is 0, 5 - 4 cm. Perhaps spontaneous permission of elements.

Keratoakantoma.

Keratoakantoma – the benign tumor which is characterized by rapid growth, a cyclic current and tendency to self - healing. Represents the dense knot towering over skin, it is frequent with the zapadeniye in the center filled with horn masses. The knot quickly grows, in 1 month has the maximum size of 1, 5 - 3 cm a diameter then growth stops, and in 6 - 12 months can be resolved with formation of a hem. The most frequent localization of a tumor – a face, hands. Meets at men at advanced age more often, but it can be observed also at children. Seldom can ozlokachestvlyatsya.

Pigmentary nevus.

Pigmentary nevus – group of the good - quality new growths developing from cages of melanogenny system – melanotsit which differently are called nevusny cages. The clinical picture of a pigmentary nevus is various. All of them are united by the characteristic color of rashes (from yellowy - brown to black) caused by various concentration of content of melanin. Most often they look as pigmentary spots of various size and smooth flat papules, but can have an appearance of huge plaques with a papillomatozny surface. A pigmentary nevus can be densely covered with hair.

Some pigmentary nevus of a melanomoopasna, i. e. under the corresponding conditions is capable to be transformed to a melanoma. A boundary pigmentary nevus which melanotsita are located in a zone of a bazalny membrane of epidermis possess the most expressed ability to a malignization. Clinically they represent black or dark gray spots (papules) with the plain smooth surface deprived of pushkovy hair. They can be localized on any sites of skin, but the most melanomoopasny are those from them which are located on palms, soles and genitals.

Dermatofibroma.

Dermatofibroma (fibroma) – the benign tumor of connecting fabric representing a semi - spherical papule or knot. The tumor arises in the lower extremities and open parts of the body more often (in the places which are exposed to a travmatization and stings of insects). Fibromas represent the dense semi - spherical strongly pigmented small knots or knots acting over a skin surface, the sizes 0, 5 - 3 cm. Rashes develop at any age and do not tend to progressing. Quantity of elements – from single to multiple.

Angioma.

Angioma represent the benign tumors consisting of the changed walls of vessels of different types (blood and lymphatic capillaries, faded, arteries, veins). The capillary gemangioma is characterized by vascular spots of various size, with the uneven borders, rose - red or cherry coloring which are turning pale at a diaskopiya. Surface of spots flat, equal, sometimes slightly towering. Favourite localization – the person.

The star - shaped gemangioma represents a red small knot from which beams vascular branches depart. Localization is more often on a face – in a nose and cheeks.

The Kavernozny gemangioma has an appearance of soft knot, from 1 do5 the cm with a hilly surface which sometimes is falling down at a palpation. Color of education varies and depends on depth of its bedding in skin. A superficial gemangioma cyanotic - red, deep – with a bluish shade.

Lipoma.

Lipoma – the benign tumor of fatty tissue coming from fatty cages – lipotsit. The tumor represents soft, often lobular knot, from several to tens centimeters, often acting over a skin surface. Coloring of skin over a lipoma is not changed. Tumors can be both single, and multiple.

MALIGNANT TUMOURS OF SKIN.

Bazalioma.

Bazalioma (bazalno - cellular epitolioma) – the most widespread malignant tumor of an epithelium which develops from atypical bazalny cells of epidermis and a follicular epithelium. It is characterized by the slow growth which is followed by an inflammatory infiltration and destruction of surrounding fabric, and also lack of a tendency to a metastazirovaniye. Occurs mainly at persons of advanced and senile age. The most frequent localization – the person, hairy part of the head. Bazalioma begins with the advent of a single dense flat or semi - spherical papule with a diameter of 2 - 5 mm, slightly pinkish or colors of normal skin. Subjective feelings are absent. The papule slowly grows and within several years reaches 1 - 2 cm. At the same time, its central part breaks up and becomes covered by a bloody crust at which rejection easily bleeding erosion or a superficial ulcer is found. On its periphery the narrow roller, continuous or consisting of separate miliarny small knots, slightly pinkish coloring is observed. Its coloring can sometimes be nacreous or dark brown. The formed ulcer, increasing in sizes, at the same time cicatrizes in the central part.

Depending on nature of growth, Bazalioma can turn: in big (10 cm and more) a flat plaque with the shelled surface; In much the fungoid knot acting over a skin surface; in the deep ulcer destroying the subject fabrics including bones.

Ploskokletochny cancer.

Ploskokletochny cancer of skin (skvamozno - cellular carcinoma) – the malignant tumor beginning in epidermis and turning into an invasive metastatic tumor. The disease meets by 10 times less than a bazalioma, at men twice more often than at women. The white patients living in the tropical solar countries (Central America, Australia, etc. ) are most subject to development of neoplastic process . Skvamozno - kletochnaya the carcinoma can begin on any site of an integument and mucous membranes, is the most frequent in places of their transition each other (lips, genitals). Originally there is a small infiltrate, with slightly towering giperkeratotichny surface of gray or yellowy - brown color. Subjective feelings in an initial stage are absent. The tumor size, beginning with several millimeters, gradually increases to 1 cm then the dense knot which then quickly reaches walnut size is already defined. Depending on the direction of growth, the tumor can or act over a skin surface, or sprout in depth of fabrics, being exposed to disintegration with formation of ulcers. This option of growth of a spinotsellyulyarny epitelioma leads to destruction not only skin, but also the subject fabrics (muscles, bones), and also tends to a fast metastazirovaniye at first in regionarny lymph nodes, and then and in other bodies. The tendency to healing of an ulcer is absent, local painful pains develop, the general exhaustion and secondary infectious complications develop further.

Melanoma.

The melanoma is the most malignant tumor of skin, develops from melanotsit and tends to a fast metastazirovaniye. The melanoma occurs much less often than a bazalioma and a skvamozno - cellular carcinoma, mainly at the persons of Caucasian race which are exposed to excess insolation, usually after the pubertatny period. The tumor can arise on any site of skin, including a nail bed or initially (on invariable skin), or again (in 30% of cases) as a result of a malignization of a pigmentary nevus, for example, owing to its chronic travmatization. The melanoma represents easily bleeding papule or the flat, slightly raised, dome - shaped or hilly knot with uniform coloring, dark brown or black with a bluish shade. Sometimes separate sites of a tumor can be deprived of coloring, and in rare instances the melanoma may contain not a pigment of melanin at all. Owing to an early metastazirovaniye, at first about primary knot there are dense pigmented semi - spherical small knots, and subsequently – the multiple pigmented and depigmented small knots and knots scattered on all body. Metastasises appear also in internals, and, as a rule, earlier, than disintegration of primary tumor begins.

Kaposha's sarcoma.

Kaposha's sarcoma (Kaposha's illness) represents the malignant tumor caused by multifocal proliferation in skin and internals of the cages covering from within blood and lymphatic vessels and also okolososudisty soyedinitelnotkanny cages.

Etiology of an illness of a multifaktorn. Participation of onkogenny viruses (a cytomegalovirus, Epstein - Burra's virus), a local trauma, genetic predisposition is supposed. Pathological process develops at the immunocompromised patients (senile age, the previous immunosupresivny therapy, HIV infection) and patients with endocrine diseases more often.

Allocate the following clinical forms of a malignant tumor Kaposha's sarcoma: 1) classical (sporadic, idiopathic); 2) immunosupressivny; 3) endemichesky; 4) epidemic (connected with HIV infection).

Displays of classical sarcoma of Kaposha are characterized by initial symmetric damage of skin, as a rule, of the lower extremities, and sometimes, brushes and forearms. More often men of advanced and senile age suffer (after 60 years). Rashes represent slightly edematous red - brown or bluish - violet spots and small knots which gradually turn into flat infiltrirovanny plaques and painful knots. Fresh knots develop at the edges of primary centers, merge with them, forming different degree of density larger hilly tumoral infiltrates. Separate elements are spontaneously resolved, leaving the pigmented, slightly atrofichny spots.

The illness has a chronic current and proceeds for years, is long being limited to damage of the same parts of the body (foot, a shin, a brush). Gradually around knots the expressed hypostasis of surrounding fabrics causing a slonovost of extremities develops. There comes the dissemination of rashes, lymph nodes increase, skin of a trunk, genitals, faces, mucous membranes of a nose and an oral cavity, internals is surprised (a digestive tract, kidneys, a liver, lungs).

The Immunosupressivny form of an illness develops at patients, is long applying immunodepressants (concerning organ transplantation, autoimmune diseases, malignant lymphoma, etc. ) and clinically reminds a classical form. Cancellation of immunosupressivny therapy often leads to recovery.

Endemichesky sarcoma of Kaposha is observed in endemic on Epstein - Burra's viruses, a cytomegalic inclusion disease and HIV infection geographical regions of the Equatorial Africa (especially in Uganda) at aboriginals. Occurs at young patients (25 - 40 years), mainly at men, and also children of both sexes.

Epidemic sarcoma of Kaposha is one of clinical diagnostic symptoms of AIDS as arises at HIV - positive patients (in any period of an infection).

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